ea0016s20.1 | Translational highlights | ECE2008
Acunzo Julie
, Roche Catherine
, Thirion Sylvie
, Gunz Ginette
, Saveanu Alexandru
, Germanetti Anne Laure
, Fusco Alessandra
, Couderc Bettina
, Enjalbert Alain
, Barlier Anne
Somatotroph adenoma represent 20% of pituitary adenoma. Although often considered as benign, they can induce serious neurological and metabolic complications. GH hypersecretion can be inhibited by somatostatin agonists such as octreotide or lanreotide. However, some GH levels reach normal values in only 50% of treated patiens. The decreased sensitivity to the somatostatin agonists was shown to be related to a lower expression of the sst2 gene.To reverse ...